2017-2018 Academic Catalog 
    
    Aug 19, 2022  
2017-2018 Academic Catalog [ARCHIVED CATALOG]

Courses


 
  
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    ASL 1010 - American Sign Language I


    An introduction to American Sign Language (ASL), including grammar, basic vocabulary, manual alphabets/numbers, and visual gestural communication. ASL written code will also be covered.

  
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    ASL 1020 - Beginning American Sign Language II


    A continuation of American Sign Language (ASL) I, including grammar, basic vocabulary, manual alphabets/numbers and visual gestural communication. ASL written code will also be covered.

    Prerequisites: ASL 1010 - American Sign Language I  

    Program of Liberal Studies (PLS) Designation: LP (summer only)

    Anticipated Terms Offered: varied

  
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    ASL 1030 - Beginning American Sign Language III


    A continuation of ASL II, this course will focus on further development of visual-spatial orientation and manipulation skills, sign vocabulary and complex sentence structures. Students will continue to work on strategies for opening, sustaining and closing general conversations on a range of topics. They will also further develop the ability to question, narrate and give increasingly detailed descriptions of activities, interactions, plans and directions. Prerequisite: Beginning American Sign Language II.

    Prerequisites: American Sign Language II.

    Anticipated Terms Offered: varied

  
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    ASL 1040 - American Sign Language IV


    A continuation of ASL III, focusing on further development of visual-spatial orientation and manipulation skills, sign vocabulary and conversational skills. Students will continue to work on strategies for opening, sustaining and closing general conversation on a range of topics. They will also further develop the ability to question, narrate and give increasingly detailed description of activities, interactions, plans and directions.

    Prerequisites: ASL 1030 - Beginning American Sign Language III 

    Anticipated Terms Offered: varied

  
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    ASTR 001 - Exploring the Universe


    Concepts, methods, and observations in astronomy, especially designed for students with little background in the sciences.  The course proceeds outward from the earth and its companion planets in the solar system to the stars and the processes that explain their brilliance in the night sky, and then onward to the galaxies and the structure of the universe as a whole.  Along the way, ideas from physics, chemistry, biology, and geology are discussed.  During the final weeks of the semester, we explore what and how scientists have learned about the history of the universe, the development of life on earth, and the likelihood of life elsewhere in the universe.  One- to two-hour evening observation sessions are a required part of the course, connecting the ideas discussed in the classroom and the textbook to the real world directly visible in the skies around us.  Not available to students who have taken Astronomy 002.  Fulfills the Scientific Perspective.

    Program of Liberal Studies (PLS) Designation: SP

    Anticipated Terms Offered: Offered every fall

  
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    ASTR 002 - The Planets and Space Exploration


    Covers much of the same material as ASTR 001 , but with more emphasis on the solar system and past and future projects for its exploration. Topics include the sun, comets and asteroids, planetary and satellite surfaces, and planetary interiors and atmospheres. The principles of rocket flight and the motion of objects in the solar system are treated qualitatively and with simple algebra. Weekly evening observation sessions - required as part of the work of the course - connect the wide-ranging lecture and textbook topics to the real world visible in the skies. Additional appropriate observations may also be assigned from time to time. Not available to students who have taken ASTR 001 . Fulfills the Scientific Perspective.

    Program of Liberal Studies (PLS) Designation: SP

    Anticipated Terms Offered: Offered every spring

  
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    BCMB 131 - Recombinant DNA


    A laboratory-oriented course designed to introduce recombinant DNA methodology. Students undertake a semester-long project, which will vary each time the course is offered. A typical project might involve construction of a genomic library, isolation of specific clones from the library and characterization of these clones. Methods usually include DNA purification, Southern blot hybridization, restriction enzyme mapping, bacterial transformation, polymerase chain reaction (PCR) and DNA sequencing.


     

    Prerequisites:

      or permission of instructor.

     

    Anticipated Terms Offered: Offered every year.

  
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    BCMB 228 - Molecular Genetics


    Explores recent discoveries in the molecular genetics of prokaryotes and eukaryotes, with emphasis on new findings related to catalytic activities of RNA. Topics include: protein synthesis, RNA transcription, gene regulation, RNA splicing, catalytic RNA and origins of living systems. Intended primarily for seniors and graduate students.

    Prerequisites: BCMB 271  or BIOL 118  or permission of instructor.

    Anticipated Terms Offered: Offered every year

  
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    BCMB 237 - Chemistry and Biology of Medicine


    Modern Medicines, ranging from anti-HIV treatments to cholesterol-lowering drugs, have become completely interwoven into society. This course explores a wide range of diseases and medicines with emphasis on how drugs interact with biological systems at the molecular-level to comat infections and diseases.  In addition to looking at currently available medicines, much of the course material uses recent journal articles to show examples of modern scientific research during the process of developing new drugs and related scientific kowledge.  This course is intended for juniors, seniors, and graduate students with strong backgrounds in both organic chemistry and biochemistry. (Prerequisites for undergraduates are CHEM 131 and BCMB 271, with a B- minimum in each.) Substantial class participation will be expected, and evaluations include exams, written papers, and oral presentations

    Prerequisites:   Organic Chemistry I and   

    Anticipated Terms Offered: Spring

  
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    BCMB 244 - Bioanalytical Chemistry


    The primary objective of this course is to introduce both theoretical and practical aspects of several current techniques, including metabolomics/synthetic biology, mass spectrometry, gas and liquid chromatography, protein chemistry, proteomics, enzyme kinetics, spectroscopy and other selected topics, in the biological systems.  The laboratory component of the course will be devoted to carrying out a research project on metabolomics and transcriptomics using chromatography/mass spectrometry, enzyme activity assays, and gene expression analyses. 

    Prerequisites: BCMB 271  and  

    Anticipated Terms Offered: Offered every other year

  
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    BCMB 264 - Biophysical Chemistry


    Emphasizes the physical chemistry of biological macromolecules- including proteins and nucleic acids. Covers the basic laws of thermodynamics, molecular thermodynamics (including aspects of modeling macromolecular structure, molecular mechanics and molecular dynamics simulations), statistical thermodynamics, physical equilibria including ligand binding, kinetics quantum mechanics and spectroscopy, and solution behavior of macromolecules. The laboratory in sillico and experimantal projects

    Prerequisites: BCMB 271 , MATH 121  or MATH 125  or permission of instructor.

    Anticipated Terms Offered: Offered every spring

  
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    BCMB 266 - Biomolecular NMR


    Covers theory and application of multidimensional nuclear magnetic resonanace (NMR) spectroscopy for the study of structure and dynamics of biomolecules in solution.

    Anticipated Terms Offered: Offered periodically

  
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    BCMB 271 - Biochemistry I


    A comprehensive survey of biochemistry and molecular biology, including protein structure, enzyme kinetics, membrane structure, DNA structure, replication, transcription and translation. The laboratory introduces basic techniques including buffer preparation, protein isolation and identification, purification of enzymes, enzyme kinetics, gel electrophoresis, column chromatography and DNA isolation and characterization.

    Prerequisites: CHEM 101 /CHEM 102 ; BIOL 100 , BIOL 101 , or BIOL 103 , and BIOL 102 ; and CHEM 131  (or permission).

    Anticipated Terms Offered: Offered every year

  
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    BCMB 272 - Biochemistry II


    A comprehensive survey of the carbohydrates, energy metabolism and metabolic biochemical pathways. Topics include glycolysis, TCA cycle, oxidative and photosynthetic phosphorylation, catabolism and anabolism. The discussion section reviews articles from the literature on recombinant DNA, inter - and intracellular signal transduction, enzymology, and other current topics.

    Prerequisites: CHEM 132  or CHEM 134  and BCMB 271 .

    Anticipated Terms Offered: Offered every year

  
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    BCMB 275 - Protein Chemistry


    An in-depth discussion on protein structure and function. Techniques routinely used to determine protein structure, function, and the underlying principles of enzyme catalysis will be examined.  Topics include protein structure hierarchy, physicochemical properties that govern protein folding, enzyme cofactors, protein synthesis and degradation, recombinant protein expression systems, protein purification methods, enzyme assays and protein quantification, posttranslational modifications, isotopic and fluorescent protein labeling strategies, mass spectrometry with proteins and peptides, protein-protein/DNA/RNA interactions, X-ray crystallography, 2D and 3D NMR spectroscopy with proteins, and protein structure visualization.

    Prerequisites: BCMB 271  or permission of instructor.

    Anticipated Terms Offered: Offered every other year

  
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    BCMB 276 - Chemical Biology - techniques and applications in research


    An in-depth discussion of tools and techniques of chemical biology and its applications in research, with a focus on cancer research. After discussion of the chemical tools, we shall study current research utilizing these tools to address biological problems.  Some techniques that will be covered are chemical and biological library synthesis, library screening methods, quantitative techniques such as Fluorescence polarization, Surface Plasmon Resonance, Isothermal Calorimetry. Biological research problems such as kinase inhibition, modulation of protein protein interactions, targeted protein degradation in live cells and live cell imaging using biorthoganal reporters will be discussed.

    Prerequisites: BCMB271 and senior or instructor permission

    Anticipated Terms Offered: Annually

  
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    BCMB 279 - Computers in Biochemistry


    The course will provide a hands-on experience using computers to analyze chemical and biochemical systems. Students will be introduced to the use of relevant Web-based and commercial/academic software packages. The exact topics to be covered may vary from year to year as new software packages become available.  Topics will include retrieval and analysis of DNA and protein sequence information from national databases; use of sequence information to identify homologous nucleic acids or proteins and predict protein secondary and tertiary structures; simulations of protein dynamics and ligand binding; and structure-based protein ligand design.

    Prerequisites: BCMB 271 .

    Anticipated Terms Offered: Offered periodically

  
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    BCMB 297 - Honors


    Departmental honors in biochemistry and molecular biology requires laboratory research, a thesis and a seminar.

    Anticipated Terms Offered: Offered every semester

  
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    BCMB 298 - Internship


    Internships are arranged through the Career Services Office. Students may register under BCMB 298 provided that the Clark internship supervisor is a member of the Biochemistry and Molecular Biology program. May be repeatable for credit.

    Anticipated Terms Offered: Offered every semester

  
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    BCMB 299 - Directed Study


    For majors seeking research experience in BCMB.  Involves a laboratory research project.  Offered for variable credit. May be repeatable for credit.

    Prerequisites: Permission of the faculty research mentor

    Anticipated Terms Offered: Offered every semester

  
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    BCMB 317 - Research


    This is a variable unit graduate course for students engaged in research at the PhD level.

    Anticipated Terms Offered: Every Semester, including summers

  
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    BCMB 328 - Molecular Genetics


    Explores recent discoveries in the molecular genetics of prokaryotes and eukaryotes, with emphasis on new findings related to catalytic activities of RNA. Topics include: protein synthesis, RNA transcription, gene regulation, RNA splicing, catalytic RNA and origins of living systems. Intended primarily for seniors and graduate students.

    Anticipated Terms Offered: Offered every year

  
  •  

    BCMB 337 - Chemistry and Biology of Medicine


    Modern medicines, ranging from anti-HIV treatments to cholesterol-lowering drugs, have become completely interwoven into society.  This course will explore a wide range of diseases and medicines with emphasis on how drugs interact with biological systems at the molecular-level to combat infections and diseases.  In addition to looking at currently available medicines, much of the course material uses recent journal articles to show examples of modern scientific reserach during the process of developing new drugs and related scientific knowledge.  This course is intended for juniros, seniors, and graduate students with strong backgrounds in both organic chemistry and biochemistry.  (Prerequisite for undergraduates are CHEM 131 and BCMB 271, with a B- minimum in each.)  Substantial class participation will be expected, and evaluations include exams, written papers, and oral presentations.

    Anticipated Terms Offered: Spring

  
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    BCMB 364 - Biophysical Chemistry


    Emphasizes the physical chemistry of biological macromolecules including-proteins and nucleic acids. Covers the basic laws of thermodynamics, molecular thermodynamics (including aspects of modeling macromolecular structure, molecular mechanics and molecular dynamics simulations), statistical thermodynamics, physical equilibria including ligand binding, kinetics quantum mechanics and spectroscopy, and solution behavior of macromolecules. The laboratory includes in silico and experimental projects.

    Prerequisites: BCMB 371

    Anticipated Terms Offered: Offered Every Year

  
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    BCMB 366 - Biomolecular NMR


    Covers theory and application of multidimensional nuclear magnetic resonanace (NMR) spectroscopy for the study of structure and dynamics of biomolecules in solution.

    Anticipated Terms Offered: Offered periodically

  
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    BCMB 371 - Biochemistry I


    A comprehensive survey of biochemistry and molecular biology, including protein structure, enzyme kinetics, membrane structure, DNA structure, replication, transcription and translation. The laboratory introduces basic techniques including safe use of radioisotopes, isolation of proteins, purification of enzymes, enzyme kinetics, gel electrophoresis, column chromatography and DNA isolation and characterization.

    Prerequisites: CHEM 101 /CHEM 102 ; BIOL 100 , BIOL 101 , or BIOL 103 , and BIOL 102 ; and CHEM 131  (or permission).

    Anticipated Terms Offered: Offered every year

  
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    BCMB 372 - Biochemistry II


    A comprehensive survey of the carbohydrates, energy metabolism and metabolic biochemical pathways. Topics include glycolysis, TCA cycle, oxidative and photosynthetic phosphorylation, catabolism and anabolism. The discussion section reviews articles from the literature on recombinant DNA, signal transduction and other current topics.

    Prerequisites: CHEM 132  or CHEM 134  and BCMB 271 .

    Anticipated Terms Offered: Offered every year

  
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    BCMB 375 - Protein Chemistry


    Presents an in-dept view of protein structures and molecular properties, and discussions of how structure and properties are inextricably linked to biological function.  Topics discussed include: chemical properties of polypeptides, biosynthesis of proteins, posttranslational modifications, evolutionary and genetics origins of protein sequences, physical interactions that determine the properties of proteins, the folded conformations of proteins, proteins in solution and in membranes, interaction of proteins with other molecules, enzyme catalysis and protein degradation.  This course has a computational component which will provide students with hands-on learning experience.

    Prerequisites:   or permission of instructor

    Anticipated Terms Offered: Every other year

  
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    BCMB 376 - Chemical Biology - techniques and applications in research


    An in-depth discussion of tools and techniques of chemical biology and its applications in research, with a focus on cancer research. After discussion of the chemical tools, we shall study current research utilizing these tools to address biological problems.  Some techniques that will be covered are chemical and biological library synthesis, library screening methods, quantitative techniques such as Fluorescence polarization, Surface Plasmon Resonance, Isothermal Calorimetry. Biological research problems such as kinase inhibition, modulation of protein protein interactions, targeted protein degradation in live cells and live cell imaging using biorthoganal reporters will be discussed.

    Prerequisites: BCMB271or instructor permission

    Anticipated Terms Offered: Annually

  
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    BCMB 379 - Computers in Biochemistry


    The course will provide a hands-on experience using computers in analyze chemical and biochemical systems. Students will be introduced to the use of relevant Web-based and commercial/academic software packages.  The exact topics to be covered may vary from year to year as new software packages become available.  Topics will include retrieval and analysis of DNA and protein sequence information from national databases; use of sequence information to identify homologous nucleic acids or proteins and predict protein secondary and tertiary structures; simulations of protein dynamics and ligand binding; and structure-based protein ligand design.

    Prerequisites:   

    Anticipated Terms Offered: Offered Periodically

  
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    BCMB 399 - Directed Study


    Graduate students construct an independent study course on a topic approved and directed by a faculty member. Offered for variable credit. May be repeatable for credit.

    Anticipated Terms Offered: Every Semester

  
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    BIOL 084 - Biodiversity


    Students will explore the diversity of life on earth and the mechanisms by which this diversity is thought to have been generated. The implications of loss of biodiversity will be considered, as well as the causes of biodiversity decline. Conservation issues will be addressed. Fulfills the Science Perspective. Not for biology majors. Offered every year.

    Program of Liberal Studies (PLS) Designation: SP

    Anticipated Terms Offered: Offered every year

  
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    BIOL 101 - Introduction to Biology I


    The goals of this two-semester course are: (1) to provide an understanding of the unifying themes in modern biology, (2) to introduce the diversity of life at all levels of organization, and (3) to illustrate the methods and modes of scientific inquiry currently used in the biological sciences. During the fall semester (BIOL 101) the focus is on fundamental principles of evolution and genetics, whereas in the spring (BIOL 102) the diversity of life, from cells to organisms, is explored. The two courses do not have to be taken in sequence but both are pre-requisites for all advanced courses in biology.

    Corequisites: Must register for lab for BIOL 101.

    Program of Liberal Studies (PLS) Designation: SP

    Anticipated Terms Offered: Offered every year.

  
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    BIOL 102 - Introduction to Biology II


    The goals of this two-semester course are: (1) to provide an understanding of the unifying themes in modern biology, (2) to introduce the diversity of life at all levels of organization, and (3) to illustrate the methods and modes of scientific inquiry currently used in the biological sciences. During the fall semester (BIOL 101) the focus is on fundamental principles of evolution and genetics, whereas in the spring (BIOL 102) the diversity of life, from cells to organisms, is explored. The two courses do not have to be taken in sequence but both are pre-requisites for all advanced courses in biology.

    Program of Liberal Studies (PLS) Designation: SP

    Anticipated Terms Offered: Offered in sequence every year

  
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    BIOL 105 - Evolution


    An introduction to the mechanisms and patterns of evolutionary change. Although this course will briefly survey the major evolutionary events that have occurred since life first evolved, the emphasis will be on mechanisms of evolutionary change (e.g. mutation, natural selection, genetic drift and gene flow) and resultant patterns (e.g. phylogenetic pattern, coevolution, stasis, adaptive radiation).

    Prerequisites: BIOL 100 , BIOL 101  or BIOL 103 , and BIOL 102 , or permission.

    Anticipated Terms Offered: Offered every year.

  
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    BIOL 106 - Introductory Biostatistics


    An introduction to mathematical and statistical methods that are most useful to biologists, this course provides skills that are useful in organizing and summarizing data, graphic methods of data presentation, and testing hypotheses based on experimental results. Key mathematical methods for describing biological phenomena are included, along with basic techniques for identifying differences among groups and relationships among variables. This course may be used by biology majors to fulfill part of their mathematics requirement. Alternatively, it may be counted among the required 10 biology courses for the major.

    Prerequisites: BIOL 101  or BIOL 103 , and BIOL 102 , and one semester of calculus (MATH 120  or MATH 124 ).

    Program of Liberal Studies (PLS) Designation: FA

    Anticipated Terms Offered: Offered every year.

  
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    BIOL 109 - Microbiology


    Introduces the fundamental principles and methods of microbiology with applications to the biomedical and environmental sciences. In the laboratory, students will isolate, cultivate, and characterize an unknown microorganism, and then identify the organism using modern molecular methods.

    Prerequisites: BIOL 101  or BIOL 103 , BIOL 102  and CHEM 102 ; or permission of instructor.

    Anticipated Terms Offered: Offered every year

  
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    BIOL 110 - Introduction To Botanical Diversity


    Biodiversity and structure of plants, protists and fungi are examined in a phylogenetic context. The evolution of photosynthetic mechanisms, transport systems and nutritional modes are considered, as are the ecological and economic significance of plants and other organisms traditionally studied by botanists.

    Prerequisites: BIOL 100 , BIOL 101  or BIOL 103 , and BIOL 102 .

    Anticipated Terms Offered: Offered every other year.

  
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    BIOL 111 - Comparative and Human Anatomy


    During the Vertebrate and Human Comparative Anatomy Course, students will be introduced to vertebrate anatomy. The lecture component will focus on the development and evolution of anatomy, examine the diversity of structures possessed by vertebrates, how these structures are used and function, and how they relate to one another. The laboratory component will give the students a hands-on experience with anatomy. The labs will focus on dissection of the shark and cat, with material from a diversity of vertebrates available for comparison and evolutionary context. The course assumes that students are familiar with general biology, and knowledge of evolution is recommended, although not required.

    Prerequisites: BIOL 101, BIOL 103, and BIOL 102

    Program of Liberal Studies (PLS) Designation: SP

    Anticipated Terms Offered: every year

  
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    BIOL 114 - Marine Biology


    Introduces the diversity and ecology of life in the oceans. Studies of basic physical oceanography and marine ecology precede studies of marine ecosystems such as salt marshes, kelp forests, rocky shores plankton and deep seas. Also included are the relationships of marine biology to the welfare of mankind.

    Prerequisites: BIOL 100 , BIOL 101  or BIOL 103 , and BIOL 102 , or permission.

    Anticipated Terms Offered: Offered every year.

  
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    BIOL 118 - Genetics


    Investigates the nature of genes and genomes in both prokaryotes and eukaryotes. A combination of approaches from classical Mendelian and modern Molecular Genetics are explored in order to examine the inheritance of both nuclear and extranuclear genes, how genes are expressed and regulated, mutation and DNA repair, and the nature of chromosome-level mutation. Also includes an integrated laboratory that highlights many aspects of the lectures and involves a bioinformatic annotation project using a novel genome.

    Prerequisites: BIOL 101  or BIOL 103 , and BIOL 102 .

    Anticipated Terms Offered: Offered every year.

  
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    BIOL 119 - Herpetology


    During the herpetology course, students will be introduced to the diversity and biology of amphibians and “reptiles”. The lecture component will have a global and diverse focus, covering topics of phylogenetics, the origin and evolution of amphibians and reptiles, the global diversity of these taxa, and their biogeography, biology, ecology and conservation. In the laboratory component, students will learn to identify amphibians and reptiles, the anatomy of these taxa, and some field techniques that are useful for studying them. The course assumes that students are familiar with basic evolutionary theory and general biology, and that they are proficient in writing.

    Prerequisites:   , and  

  
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    BIOL 137 - Cell Biology


    The cell as a functional unit is discussed from the molecular level to the whole cell. Included are introductions to the biochemistry and metabolic roles of some of the molecules and macromolecules that are found in cells. Also discussed are the evolution, structure and function of the various subcellular organelles and the cytoskeleton. Emphasis is placed on understanding the molecular mechanisms behind cell physiology and the experimental methods used to determine those mechanisms.

    Prerequisites: BIOL 100 , BIOL 101  or BIOL 103 , and BIOL 102 .

    Anticipated Terms Offered: Offered every year.

  
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    BIOL 143 - Neuroscience


    Biology 143 introduces students to the biology of nervous systems and their relationship to behavior and disease.  Mammalian nervous systems are emphasized, but from a comparative standpoint.  The course covers topics ranging from neuronal structure and function, synaptic communication, and intra- and intercellular signaling systems, to the development and regeneration of nervous systems, the processing of sensory information, and complex functions such as learning, memory, cognition, and emotion.

    Prerequisites: BIOL 111   , BIOL 118  , or  

    Anticipated Terms Offered: Offered every year.

  
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    BIOL 144 - Bioethics: stem cells, embryos and reproduction


    One of the critical challenges in modern science is our ability to shape human development.  This has brought embryology into the public domain.  Based on our current scientific understanding of the development of the embryo we now have the ability to plan the sex of our children, test for the presence of certain genes and abort those embryos that do not meet certain genetic criteria and clone human cell nuclei to produce stem cells identical to patients who might need them.  The questions we now face are: Even if we can do these things, should we do them?  Under what conditions should such procedures be allowed or forbidden?  Do we wish to support the research that will make such procedures possible?  Using a primarily discussion-based format we will explore the science surrounding these recent technological advances in embryological sciences and address some of the key associated societal and ethical concerns.

    Program of Liberal Studies (PLS) Designation: VP

    Anticipated Terms Offered: Fall

  
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    BIOL 180 - Introduction to Fungal Biology


    This is a lecture/lab/field course focused on the diversity, ecological roles, and evolution of fungi. Particular emphasis will be placed on diversity of macrofungi (mushrooms) of New England. Students will learn basic techniques for identification of fungi using morphological and anatomical characters, as well as DNA sequences. Fungi will be collected in the field (including the Hadwen Arboretum and other habitats visited during field trips) and selected species will be brought into pure culture and fruited in the lab. Additional topics will include plant pathology, medical mycology, emerging infectious diseases of humans and wildlife, applied fungal biology, and ethnomycology.

    Prerequisites: BIOL 101  or BIOL 103 , and BIOL 102 .

    Anticipated Terms Offered: Offered every other year

  
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    BIOL 201 - Ecology of Atlantic Shores


    This course explores the ecology of marine organisms found in diverse Atlantic habitats, ranging from the rocky intertidal of New England to the coral reefs of Bermuda. The course includes lectures, field research, and a one-week trip to the Bermuda Biological Station for Research during semester break. Students must pay a fee (approximately $2100) for the cost of lodging, meals and airfare to Bermuda.

    Prerequisites: BIOL 101  or BIOL 103 , and BIOL 102 . Recommended: BIOL 114  or BIOL 216 .

    Anticipated Terms Offered: Offered every other fall.

  
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    BIOL 206 - Advanced Biostatistics


    During Advanced Biostatistics, students will build on the basic statistical skills they gained in Quantitative Methods and learn to apply more advanced techniques to real data.  Students will also learn to read biostatistical literature, which will build their ability to learn other statistical techniques on their own.  Students will learn a variety of techniques that are frequently used by Biology Faculty at Clark University, and so will enhance the skills students have to effectively do research in the department.  Students will learn to do these statistics in the statistical computing language R, which has become the standard in the sciences for conducting complex statistical analysis.  Students will get the opportunity to analyze data generated in Clark Biology laboratories to reinforce their learning and get valuable hands-on experience doing statistics.

    Prerequisites:

      or permission of the instructor

    Anticipated Terms Offered: every other fall

  
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    BIOL 208 - Conservation and Effective Practice


     

    This course is designed to introduce students to the conceptual, ecological, evolutionary, and practical concepts associated with local conservation issues in anthropogenically-influenced local environments.  Students will use the expertise gained in earlier courses in evolution, genetics and ecology to solve applied problems likely to be associated primarily with the Clark campus, the arboretum and local environments closely associated with the University.  Classes will consist of both discussions of fundamental literature related to conservation biology, selected for relevance to the applied problem the course is intended to solve, and of discussions of targeted applied literature led by practitioners in the appropriate field.  The goal of this course over the long-term is to enhance the sustainability of Clark University from biological and conservation perspectives.

    Prerequisites:

      and  

    Anticipated Terms Offered: spring

  
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    BIOL 209 - The Genome Project


    The Genome Project offers students a unique opportunity to directly apply the bioinformatics and comparative genomics skills acquired during Introduction to Bioinformatics (BINF 101) in the analysis of a novel genome. Each year, students will work collaboratively in small research teams to piece together the entire DNA blueprint of an organism with no existing reference genome. Students will evaluate and apply genome assembly, gene prediction, functional annotation, and variant discovery algorithms to better understand the genome structure, and functional biology of sequenced organisms. Analysis will be conducted within a LINUX environment through the Clark University Supercomputing Cluster.

    Prerequisites: MBB 101  

    Anticipated Terms Offered: Spring

  
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    BIOL 210 - Genomics Seminar


    Sequenced genomes provide powerful new tools for life scientists. Through reading primary literature, students will gain an appreciation for how sequenced genomes have changed the way in which biologists design experiments. The limitations of genomics will also be discussed. Readings will be drawn from various disciplines within the biological sciences, and will demonstrate how genomes have enhanced our understanding of issues relating to human health, biotechnology, agriculture and the environmental sciences. This course will provide an introduction to some of the available genome databases.

    Prerequisites: BIOL 118

    Anticipated Terms Offered: n/a

  
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    Biol 212 - Microbiomes


    The course will explore current research on microbiomes found in a variety of habitats:  human and plant associated, marine, and soil. Through a mixture of lectures and discussions, students will learn about core ecological concepts relevant to microbiomes and microbiology. Throughout the course, students will read primary scientific literature and gain practical skills in how to understand and interpret research articles. Students will learn about current sequencing and molecular techniques (including 16S rDNA sequncing, metagenomics, and metatranscriptomics) used to study microbiomes. Each student will give a final presentation on a microbiome research article of their choice.

    Prerequisites: BIOL 109  - Microbiology

    Anticipated Terms Offered: Spring Annually

  
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    BIOL 216 - Ecology


    Provides an overview of ecology as a scientific discipline. The primary emphasis is on efforts to explain and predict the distribution and abundance of organisms, how ecological communities are composed and why they vary in time and space. Course website http://clarku.edu/faculty/tlivdahl/Ecology/index.html

    Prerequisites: One or more courses from the organismal biology group and one college-level math course.

    Anticipated Terms Offered: Offered every year

  
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    BIOL 217 - Ecology of Infectious Disease


    Explores the relationship between infectious disease agents and their hosts and how that interaction can effect changes in the abundance of host and pathogen populations. Factors that contribute to the occurrence and persistence of epidemics, the evolution of virulence and transmission and strategies for controlling epidemics will be considered using theoretical approaches and case studies of diseases affecting humans and other hosts. A wide spectrum of human diseases will be considered, including human pathogens of recent concern (examples include HIV, Lyme Disease, West Nile Virus) and of historic and continuing importance (e.g., schistosomiasis, bubonic plague, malaria, smallpox, yellow fever).

    Prerequisites: BIOL 216 , or by permission.

    Anticipated Terms Offered: Offered periodically.

  
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    BIOL 218 - Genetics and Disease


    This course focuses on the genetic basis of human disease. Many important disorders are primarily of genetic origin, whereas others reflect the complex interplay between our genes and the environment. The Human Genome Project has provided a wide range of new tools that allow us to understand the genetic underpinnings of both kinds of disease. The course uses a mixed format, with both lecture and discussion of primary literature; students will also pick a human disorder/disease and present a literature review of it in the form of an essay and a poster presentation.

    Prerequisites: BIOL 118 .

    Anticipated Terms Offered: Offered periodically

  
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    BIOL 219 - Physiological Ecology of Marine Algae


    This course will introduce upper-division undergraduate and graduate students to algal diversity and the physiological ecology of marine algae. The course will include lectures, readings, discussions and laboratory research. Topics of discussion include evolution, biochemistry, molecular biology and physiology of photosynthetic cells. In the laboratory, students will learn various techniques including measurements of photosynthesis, determination of enzyme activity and methods used to examine gene expression. The topics and techniques covered in the course are readily applied to the physiology of a broad range of organisms.

    Prerequisites: Either BIOL 110 , BIOL 118  or BIOL 137 .

    Anticipated Terms Offered: Offered every spring.

  
  •  

    BIOL 221 - Developmental Biology


    Considers the fundamentals of development from the molecular level up to the organismal. Emphasis is placed on the major animal model systems.

    Prerequisites: BIOL 137  or permission of instructor.

    Anticipated Terms Offered: Offered every other year.

  
  •  

    BIOL 223 - Topics in Marine Biology


    Provides an opportunity to delve in-depth into selected topics in marine biology. This writing intensive course uses discussions of the primary literature to explore topics in genomics, microbial ecology, oceanography and marine biology. Limited to 15 students.

    Prerequisites: BIOL 114 .

    Anticipated Terms Offered: Offered every other year.

  
  •  

    BIOL 224 - Ecology of Disease Vectors


    This course provides a field-intensive, project-oriented exposure to the biology of arthropods that transmit disease, with particular emphasis on ecology of mosquitoes. Methods include quantitative sampling techniques, species identification based on morphology and DNA, detection of medically important viruses, and experimental approaches to understanding interactions among species. The primary aim for the group will be to track the course of mosquito invasions. We will process samples obtained from school groups throughout the Midwest and Mid-Atlantic States to track the progress of a mosquito introduced from Asia. We will examine in detail two invasions that are presently under way in Bermuda and conduct experiments on egg-laying behavior during a week-long field trip to Bermuda. Field trips will also include trips to wetlands and forests in New England.  $2100 fee required for travel to Bermuda.

    Prerequisites: BIOL 101 , and either BIOL 102  or BIOL 103 .

    Anticipated Terms Offered: previously approved

  
  •  

    BIOL 230 - The Human Genome


     

    This course will provide a foundation for the basic concepts in human genomics. Topics covered will include: genome structure and function, human evolution and paleogenomics, human migration, natural selection in human populations, genetic disease, microbiomics, epigenetics, and personalized medicine and ethics. The format of the course will be a combination of group projects, discussion of primary literature, and lecture.

    Prerequisites:

     ,  

    Anticipated Terms Offered: Varied

  
  •  

    BIOL 233 - Animal Locomotion


    Students will explore the functional morphology of locomotion in animals (both invertebrate and vertebrate). The material that students will learn will integrate metabolism and physiology with morphology and ecology. Students will learn how components of the locomotor system work individually, and from the perspective of the organism. The underlying basic physics of how locomotion happens will also be considered. Students will present chapters from the textbook, discuss recently published research articles related to the textbook chapters, and write a term paper that will be a literature review on an aspect of locomotion that particularly fascinates each student. Students will learn to communicate effectively using written, oral, and visual presentation, and to think critically about material they learn about.

  
  •  

    BIOL 234 - Signal Transduction


    An advanced course exploring the various molecular and biochemical pathways through which cells communicate with themselves and the extracellular environment. Topics include protein phosphorylation, G-proteins, phospholipid metabolism, the action of oncogenes and several ionic signaling pathways. Both lectures and student presentations of papers culled from current literature.

    Prerequisites: BIOL 137  or   or permission of instructor.

    Anticipated Terms Offered: Offered periodically.

  
  •  

    BIOL 236 - Biology of Cancer


    According to the World Health Organization, cancer is the cause of one in eight deaths around the world, and kills an even greater proportion of Americans. Over the past thirty years, great strides have been made in understanding the biological and environmental causes of cancer; we have also made stunning progress in the treatment of some cancers. This class will address the cellular, genetic and biochemical basis of cancer, as well as delve into current modes of treatment. Students will choose a human cancer and develop an essay, present a poster and give an oral presentation on it, based on a review of primary literature.

    Prerequisites: BIOL 137  or  BIOL 118  recommended.

    Anticipated Terms Offered: Offered periodically.

  
  •  

    BIOL 237 - Epigenetics


    With the completion of the sequencing of the human genome, where does science go now?  Many scientists have chosen to investigate our genome at the level “above genetics”, or Epigenetics. Epigenetic changes are not coded in the DNA sequence, yet they are heritable through mitotic or meiotic cell divisions.  Although epigenetic phenomena have been noted for decades, seemingly disparate observations are only now coalescing into an emerging field of Biology.  This seminar style course will investigate the molecular basis of epigenetics and allow students to present research articles and discuss the literature at the intersection of gene expression, chromosome structure, and chromatin dynamics.

    Prerequisites: BIOL 118  

    Anticipated Terms Offered: Spring

  
  •  

    BIOL 238 - Seminar in Cell Biology


    Discussion based on research papers from the current literature, will be focused on an area in cell biology selected by the participants on the first day. The weekly readings will be selected by both the students and the member. The scientific content, as well as the methodology will be discussed in detail.

    Prerequisites: BIOL 137  or permission of the instructor.

    Anticipated Terms Offered: Offered every other year.

  
  •  

    BIOL 239 - Evolutionary Developmental Biology


     

    Biology 239 is an upper level seminar in evolutionary developmental biology, or “evo-devo”.  Evo-devo is a major, emerging field that integrates organismal evolutionary biology with molecular embryology, genetics, and genomics.  The goal of this course is to understand how changes in developmental processes have given rise to the incredible biological diversity seen in nature.  We will primarily focus on the evolution of metazoan, or animal, development, but we will also discuss evolution of non-metazoan organismal development.  This course emphasizes analysis and discussion of primary literature dealing with phenomena and questions that interest evolutionary developmental biologists, including (but not limited to): 1) How embryonic development arose and evolved in the transition to multicellularity, 2) The role evolution of developmental processes plays in the evolutionary modification of existing features and the origin of novel structures, 3) Phenotypic plasticity and the linkage between genotype and phenotype, and 4) Interactions between developmental processes and environmental influences.

    Prerequisites:

     ,   or   or by instructor’s permission


    Anticipated Terms Offered: Fall only

  
  •  

    BIOL 240 - Comparative and Human Physiology


     

    Introduces the principles underlying the physical and chemical processes that maintain animal life. Lectures cover the interdependent function of molecules, cells, organs and tissues as they relate to organismal performance. Human physiology is emphasized from a comparative standpoint.

    Prerequisites: BIOL 137  or

      .   is recommended. Enrollment is normally restricted to juniors, seniors and graduate students.

    Anticipated Terms Offered: Offered every year.

  
  •  

    BIOL 242 - Animal Behavior


    Examines the causes and evolution of the behavior of animals. The largest part of this course will focus on the adaptive value and evolution of behavioral patterns, but a general overview of behavioral development and causation will be provided to offer the necessary background for interpretation of the ultimate causes of behavior.

    Prerequisites: BIOL 105  and permission of instructor.

    Anticipated Terms Offered: Offered every other year.

  
  •  

    BIOL 253 - Darwinian Medicine


    Darwinian (Evolutionary) Medicine is the application of basic evolutionary theory to medical science and public health.  Human diseases have both proximate (mechanistic) and ultimate (evolutionary) causes. The common medical approach has been to ignore the ultimate causes and, instead, focus on the proximate. Thus, we may understand the physiological processes but not the evolutionary significance. In this course, we will focus on the evolutionary causes of disease. The primary goal of this course is to teach research skills while sharpening understanding and application of Darwinian thought. To this end, students will generate hypotheses, collect and analyze data to test these hypotheses, and present the information in both oral and manuscript form.

    Prerequisites: BIOL 105  - Evolution

    Anticipated Terms Offered: Spring

  
  •  

    BIOL 254 - Molecular and Evolutionary Systematics: Assembling the Tree of Life


    Assembling, Visualizing and Analyzing the Tree of Life
    This course is designed for students who are interested in either molecular or evolutionary biology. Topics to be discussed include evolution of genes and genomes, methods used to estimate evolutionary relationships using molecular data, and applications of molecular data to general problems in biology. The course will include lectures, student-led discussions, laboratory projects using computer-based applications and presentations of these projects.

    Prerequisites: BIOL 105

    Anticipated Terms Offered: Offered periodically.

  
  •  

    BIOL 255 - Viruses: friends or foes?


    Viruses are the ultimate parasites-they hijack the molecular machinery of their host to make more copies of themselves. There are viruses that infect nearly every type of life, from bacteria to beluga whales and even other viruses! Through lectures and in-class reading of current research articles, and in-class discussion this class will explore the amazing biology of viruses, their impact on society and our planet, and several controversial topics relevant to viruses: the growing anti-vaccination movement, research on the evolution of more virulent avian flu viruses, and virus-derived genome editing technologies (e.g. CRISPR). Students will also give a final project presentation on a particular virus of their choosing.

    Prerequisites: BIOL 109  - Microbiology

    Anticipated Terms Offered: Fall annually

  
  •  

    BIOL 256 - Biology of Symbiosis


    This course focuses on the ecological and evolutionary aspects of symbioses, the intimate associations among different species that are ubiquitous in nature. Examples of symbioses include lichens, corals and pollination syndromes. Lectures introduce general theory regarding evolution and ecology of symbioses, and student-led discussions are based on primary research articles focusing on specific systems.

    Prerequisites: BIOL 100 , BIOL 101  or BIOL 103 , and BIOL 102  and BIOL 118  .

    Anticipated Terms Offered: Offered every other year.

  
  •  

    BIOL 258 - Small Scale Land Conservation in Massachusetts


    This course is designed to introduce students to the conceptual, ecological, and practical issues relating to small-scale land conservation. Study sites will be within the north-central Massachusetts region. Lectures given by the professor and local Massachusetts conservation experts will be supplemented by numerous on-site training activities. Students will learn: what ecological attributes of specific sites motive small-scale conservation effords; how various groups work together to maximize the conservation potential of small tracks of land; how land-owners and acquiring entities come to an agreement on a specific conservation document; and what ecological monitoring and other similar continuing effords (e.g., control of invasive species) are involved. Although the course will focus on the Conservation Restriction as a conservation tool, other conservation vehicles will be explored. Participating Massachusetts entities will include: The Trustees of Reservations; the Massachusetts Association of Conservation Commissioners; the North Quabbin Land Trust; and Central Massachusetts service foresters working with the Department of Conservation & Recreation.

    Prerequisites: BIOL 101/103, BIOL 102, Evolution, Ecology, and one additional “hard science” course (could be in another department, such as Geography).

    Anticipated Terms Offered: Fall semester annually

  
  •  

    BIOL 290 - Science Careers & Effective Practice


     

    Students will consider what science is, how it works, and what it means to be a scientist.  They will learn about the limits of scientific inquiry, how the scientific method works, and how to test hypotheses and interpret results.  Students will go on to study how scientists write and the types of things they write.  This will culminate in the writing of a grant proposal.  Students will also learn about and discuss scientific ethics, including the ethics behind doing good science, and those focus around publishing.  Finally, students will learn about career options in science (both academic and not), how to write a CV, give a presentation, and apply to graduate school or for other academic positions.  The goal of the course is to teach students about the rarely-discussed, but critically important aspects of being a successful scientist.

    Prerequisites: Must be Seniors. Students should be research active (working in a professor’s lab). Students will need permission to enroll.

    Anticipated Terms Offered: Spring

  
  •  

    BIOL 293 - Peer Learning Assistant


    Peer Learning Assistants (PLAs) are undergraduate students who are selected by a faculty member to facilitate teaching and learning activities.  These activities may include:  helping to prepare for or assisting in laboratory sessions, providing feedback on drafts of writing assignments, leading small group discussions, working with individual students who are having difficulty, facilitating group project work (in or out of class), and/or facilitating online discussions. It is the practice at Clark that PLAs do not grade student work.  PLAs generally work 10-15 hours per week but the precise schedule,  activities, and units earned are determined on an individual basis with the supervising faculty/staff member.  Students who receive credit for being a PLA participate in weekly meetings to review the experiences of PLAs, discuss various aspects of science education and student learning, and receive guidance on upcoming projects.  Students will provide written reflections about their experiences and goals mid-semester and a final paper based on the teaching/learning experience at the end of the semester.  This course is offered on a Pass/Fail basis.  Registration is by instructor permission only and you must choose the number of units (0.5 or 1.0). May be repeatable for credit.



    Prerequisites: Registration by instructor permission only.

    Anticipated Terms Offered: Fall and Spring

  
  •  

    BIOL 296 - Special Topics in Biology


    This course addresses current or timely topics in the study of Biology, that are in a pilot phase or are know to be one time offerings.  Special Topics can vary from semester to semester.

    May be repeated for credit

    Spring 2015 Topic: Ecology & Management of Invasive Plants

     

    Anticipated Terms Offered: varied

  
  •  

    BIOL 297 - Honors in Biology


    Readings and research for students in the honors program. May be repeatable for credit.

    Anticipated Terms Offered: Offered every year.

  
  •  

    BIOL 298 - Internship


    Independent research at off-campus sites for the purpose of broadening the backgrounds of qualified students. Each internship is guided by an on-site professional and a department faculty member. May be repeatable for credit.

    Anticipated Terms Offered: Offered every year.

  
  •  

    BIOL 299 - Directed Study


    Advanced readings or research under the direction of a department faculty member. May be repeatable for credit.

    Prerequisites: Permission of instructor.

    Anticipated Terms Offered: Offered every year.

  
  •  

    BIOL 301 - Ecology of Atlantic Shores


    This course explores the ecology of marine organisms found in diverse Atlantic habitats, ranging from the rocky intertidal of New England to the coral reefs of Bermuda. The course includes lectures, field research, and a one-week trip to the Bermuda Biological Station for Research during semester break. Students must pay a fee (approximately $2100) for the cost of lodging, meals and airfare to Bermuda.

    Prerequisites: BIOL 101  or BIOL 103 , and BIOL 102 . Recommended: BIOL 114  or BIOL 216 .

    Anticipated Terms Offered: Offered every other fall.

  
  •  

    BIOL 306 - Advanced Biostatistics


    During Advanced Biostatistics, students will build on the basic statistical skills they gained in Quantitative Methods and learn to apply more advanced techniques to real data.  Students will also learn to read biostatistical literature, which will build their ability to learn other statistical techniques on their own.  Students will learn a variety of techniques that are frequently used by Biology Faculty at Clark University, and so will enhance the skills students have to effectively do research in the department.  Students will learn to do these statistics in the statistical computing language R, which has become the standard in the sciences for conducting complex statistical analysis.  Students will get the opportunity to analyze data generated in Clark Biology laboratories to reinforce their learning and get valuable hands-on experience doing statistics.

    Prerequisites:

      or permission of the instructor

    Anticipated Terms Offered: every other fall

  
  •  

    BIOL 308 - Conservation and Effective Practice


     

    This course is designed to introduce students to the conceptual, ecological, evolutionary, and practical concepts associated with local conservation issues in anthropogenically-influenced local environments.  Students will use the expertise gained in earlier courses in evolution, genetics and ecology to solve applied problems likely to be associated primarily with the Clark campus, the arboretum and local environments closely associated with the University.  Classes will consist of both discussions of fundamental literature related to conservation biology, selected for relevance to the applied problem the course is intended to solve, and of discussions of targeted applied literature led by practitioners in the appropriate field.  The goal of this course over the long-term is to enhance the sustainability of Clark University from biological and conservation perspectives.

    Prerequisites:

      and  

  
  •  

    BIOL 309 - The Genome Project


    The Genome Project offers students a unique opportunity to directly apply the bioinformatics and comparative genomics skills they acquired during Introduction to Bioinformatics (BINF 101) in the analysis of a novel genome. Each year, students will work collaboratively in small research teams to piece together the entire DNA blueprint of an organism with no existing reference genome. Students will evaluate and apply genome assembly, gene prediction, functional annotation, and variant discovery algorithms to better understand the genome structure, and functional biology of sequenced organisms. Analysis will be conducted within a LINUX environment through the Clark University Supercomputing Cluster.

    Prerequisites: MBB 101  

    Anticipated Terms Offered: Spring

  
  •  

    BIOL 310 - Genomics Seminar


    Sequenced genomes provide powerful new tools for life scientists. Through reading primary literature, students will gain an appreciation for how sequenced genomes have changed the way in which biologists design experiments. The limitations of genomics will also be discussed. Readings will be drawn from various disciplines within the biological sciences, and will demonstrate how genomes have enhanced our understanding of issues relating to human health, biotechnology, agriculture and the environmental sciences. This course will provide an introduction to some of the available genome databases.

  
  •  

    Biol 312 - Microbiomes


    The course will explore current research on microbiomes found in a variety of habitats:  human and plant associated, marine, and soil. Through a mixture of lectures and discussions, students will learn about core ecological concepts relevant to microbiomes and microbiology. Throughout the course, students will read primary scientific literature and gain practical skills in how to understand and interpret research articles. Students will learn about current sequencing and molecular techniques (including 16S rDNA sequncing, metagenomics, and metatranscriptomics) used to study microbiomes. Each student will give a final presentation on a microbiome research article of their choice.

    Anticipated Terms Offered: Spring Annually

  
  •  

    BIOL 315 - Ecology of Infectious Disease


    Explores the relationship between infectious disease agents and their hosts and how that interaction can effect changes in the abundance of host and pathogen populations. Factors that contribute to the occurrence and persistence of epidemics, the evolution of virulence and transmission and strategies for controlling epidemics will be considered using theoretical approaches and case studies of diseases affecting humans and other hosts. A wide spectrum of human diseases will be considered, including human pathogens of recent concern (examples include HIV, Lyme Disease, West Nile Virus) and of historic and continuing importance (e.g., schistosomiasis, bubonic plague, malaria, smallpox, yellow fever).

    Prerequisites: BIOL 216  or by permission.

    Anticipated Terms Offered: Offered periodically.

  
  •  

    BIOL 316 - Ecology


    Provides an overview of ecology as a scientific discipline. The primary emphasis is on efforts to explain and predict the distribution and abundance of organisms, how ecological communities are composed and why they vary in time and space. one or more courses from the organismal biology group and one college-level math course.

    Anticipated Terms Offered: Offered every year

  
  •  

    BIOL 317 - Research


    This is a variable unit graduate course for students engaged in research at the PhD level.

    Anticipated Terms Offered: Every Semester, including summers

  
  •  

    BIOL 318 - Genetics and Disease


    This course focuses on the genetic basis of human disease. Many important disorders are primarily of genetic origin, whereas others reflect the complex interplay between our genes and the environment. The Human Genome Project has provided a wide range of new tools that allow us to understand the genetic underpinnings of both kinds of disease. The course uses a mixed format, with both lecture and discussion of primary literature; students will also pick a human disorder/disease and present a literature review of it in the form of an essay and a poster presentation.

    Prerequisites: BIOL 118 .

    Anticipated Terms Offered: Offered periodically

  
  •  

    BIOL 321 - Developmental Biology


    Considers the fundamentals of development from the molecular level up to the organismal. Emphasis is placed on the major animal model systems.

    Prerequisites: BIOL 137  or permission of instructor.

    Anticipated Terms Offered: Offered every other year.

  
  •  

    BIOL 322 - Physiological Ecology of Marine Algae


    This course will introduce upper-division undergraduate and graduate students to algal diversity and the physiological ecology of marine algae. The course will include lectures, readings, discussions and laboratory research. Topics of discussion include evolution, biochemistry, molecular biology and physiology of photosynthetic cells. In the laboratory, students will learn various techniques including measurements of photosynthesis, determination of enzyme activity and methods used to examine gene expression. The topics and techniques covered in the course are readily applied to the physiology of a broad range of organisms.

    Prerequisites: Either BIOL 110 , BIOL 118  or BIOL 137 .

    Anticipated Terms Offered: Offered every spring.

  
  •  

    BIOL 323 - Topics in Marine Biology


    Provides an opportunity to delve in-depth into selected topics in marine biology. This writing intensive course uses discussions of the primary literature to explore topics in genomics, microbial ecology, oceanography and marine biology. Limited to 15 students.

    Prerequisites: BIOL 114 .

    Anticipated Terms Offered: Offered every other year.

  
  •  

    BIOL 324 - Ecology of Disease Vectors


    This course provides a field-intensive, project-oriented exposure to the biology of arthropods that transmit disease, with particular emphasis on ecology of mosquitoes. Methods include quantitative sampling techniques, species identification based on morphology and DNA, detection of medically important viruses, and experimental approaches to understanding interactions among species. The primary aim for the group will be to track the course of mosquito invasions. We will process samples obtained from school groups throughout the Midwest and Mid-Atlantic States to track the progress of a mosquito introduced from Asia. We will examine in detail two invasions that are presently under way in Bermuda and conduct experiments on egg-laying behavior during a week-long field trip to Bermuda. Field trips will also include trips to wetlands and forests in New England. Students must pay a fee (approximately $2100) for the cost of lodging, meals and airfare to Bermuda.

    Prerequisites: BIOL 101 , and either BIOL 102  or BIOL 103 .

    Anticipated Terms Offered: Offered every year.

  
  •  

    BIOL 330 - The Human Genome


    This course will provide a foundation for the basic concepts in human genomics. Topics covered will include: genome structure and function, human evolution and paleogenomics, human migration, natural selection in human populations, genetic disease, microbiomics, epigenetics, and personalized medicine and ethics. The format of the course will be a combination of group projects, discussion of primary literature, and lecture.

    Anticipated Terms Offered: Varied

  
  •  

    BIOL 333 - Animal Locomotion


    Students will explore the functional morphology of locomotion in animals (both invertebrate and vertebrate). The material that students will learn will integrate metabolism and physiology with morphology and ecology. Students will learn how components of the locomotor system work individually, and from the perspective of the organism. The underlying basic physics of how locomotion happens will also be considered. Students will present chapters from the textbook, discuss recently published research articles related to the textbook chapters, and write a term paper that will be a literature review on an aspect of locomotion that particularly fascinates each student. Students will learn to communicate effectively using written, oral, and visual presentation, and to think critically about material they learn about.

    Anticipated Terms Offered: various

  
  •  

    BIOL 334 - Signal Transduction


    An advanced course exploring the various molecular and biochemical pathways through which cells communicate with themselves and the extracellular environment. Topics include protein phosphorylation, G-proteins, phospholipid metabolism, the action of oncogenes and several ionic signalling pathways. Both lectures and student presentations of papers culled from current literature.

    Prerequisites: BIOL 137  or BCMB 271  or permission of instructor.

    Anticipated Terms Offered: Offered periodically.

  
  •  

    BIOL 336 - Biology of Cancer


    According to the World Health Organization, cancer is the cause of one in eight deaths around the world, and kills an even greater proportion of Americans. Over the past thirty years, great strides have been made in understanding the biological and environmental causes of cancer; we have also made stunning progress in the treatment of some cancers. This class will address the cellular, genetic and biochemical basis of cancer, as well as delve into current modes of treatment. Students will choose a human cancer and develop an essay, present a poster and give an oral presentation on it, based on a review of primary literature.

    Prerequisites: BIOL 137  or   ; BIOL 118  recommended.

    Anticipated Terms Offered: Offered periodically.

  
  •  

    BIOL 337 - Epigenetics


    With the completion of the sequencing of the human genome, where does science go now?  Many scientists have chosen to investigate our genome at the level “above genetics”, or Epigenetics. Epigenetic changes are not coded in the DNA sequence, yet they are heritable through mitotic or meiotic cell divisions.  Although epigenetic phenomena have been noted for decades, seemingly disparate observations are only now coalescing into an emerging field of Biology.  This seminar style course will investigate the molecular basis of epigenetics and allow students to present research articles and discuss the literature at the intersection of gene expression, chromosome structure, and chromatin dynamics.

    Anticipated Terms Offered: Spring

  
  •  

    BIOL 338 - Seminar in Cell Biology


    Discussion based on research papers from the current literature, will be focused on an area in cell biology selected by the participants on the first day. The weekly readings will be selected by both the students and the member. The scientific content, as well as the methodology will be discussed in detail.

    Prerequisites: BIOL 137  or permission of the instructor.

    Anticipated Terms Offered: Offered every other year.

  
  •  

    BIOL 339 - Evolutionary Developmental Biology


     

    Biology 339 is an upper level seminar in evolutionary developmental biology, or “evo-devo”.  Evo-devo is a major, emerging field that integrates organismal evolutionary biology with molecular embryology, genetics, and genomics.  The goal of this course is to understand how changes in developmental processes have given rise to the incredible biological diversity seen in nature.  We will primarily focus on the evolution of metazoan, or animal, development, but we will also discuss evolution of non-metazoan organismal development.  This course emphasizes analysis and discussion of primary literature dealing with phenomena and questions that interest evolutionary developmental biologists, including (but not limited to): 1) How embryonic development arose and evolved in the transition to multicellularity, 2) The role evolution of developmental processes plays in the evolutionary modification of existing features and the origin of novel structures, 3) Phenotypic plasticity and the linkage between genotype and phenotype, and 4) Interactions between developmental processes and environmental influences.

    Prerequisites:

      or permission of the instructor

    Anticipated Terms Offered: Fall only

 

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